Fracture risk associated with different types of oral corticosteroids and effect of termination of corticosteroids on the risk of fractureswas investigated in the elderly. A review of literature showed that a majority of studies on patients over 70 years of age included only patients with known fractures as well as those with an underlying condition . This included those with osteoporosis, osteoporotic fractures, or those with other diseases of the skeletal system, oral corticosteroids comparison. The majority of patients studied were Caucasian and did not differ significantly in age or physical abilities . On the other hand, a retrospective analysis of the literature on older patients with low bone mass showed some differences in fracture risk with varying frequencies of oral corticosteroid exposure , More results. In a prospective cohort study, patients with low bone mass who were treated with oral corticosteroids for at least 2 years had a significantly increased risk of endovascular and/or coronary artery occlusive disease than those treated in a shorter time (0–12 months) in comparison with those who were treated for no more than 4 months (RR 1, oral corticosteroids philippines.6 [95% CI 1, oral corticosteroids philippines.1 – 2, oral corticosteroids philippines.5]), although the difference was only significant among males , oral corticosteroids philippines. In the present study, an analysis of a comprehensive database of fracture reports was conducted, and the incidence of low bone mass in patients on oral corticosteroids was compared with the incidence in patients who were not on oral corticosteroids for a short period of time. The risk for a fracture was compared with that in the general population; all fracture outcomes were considered and compared (except non-fracture fractures of the lower leg), as follows: fractures of the ankle, hand, and wrist; and vertebral fractures. Two-thirds of patients treated on oral corticosteroids were aged <70 years, and only 25% were over 75 years of age, oral corticosteroids and related harms. This may be explained as it is well known that the incidence of low bone mass in patients over 70 years of age is generally very low , osteoarthritis in oral corticosteroids.Methods The study had three parts that made it a multi-study investigation, oral corticosteroids in osteoarthritis. The first part was a systematic literature review. This consisted of five searches in PubMed, Medline, Embase, Web of Science (PubMed, Scopus) and CINAHL, focusing on relevant articles between July 2010 and June 2012. The search terms used were "low bone mass", "oral corticosteroid use", "treatment effect", "dose", "prescribing history", "use interval", "pre-treatment follow up", "primary outcome", "secondary outcomes", "surrogates" and "follow up", oral corticosteroids comparison.
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